Platelet magnetic nanocarriers as MRI sensors to delineate vascular injury network and targeted pre-protection in ischemic stroke

Accurate mapping the damaged vascular network is key to subsquent effective therapeutic strategy implementation in ischemic stroke. In this study, magnetic resonance imaging (MRI) based on a platelet membrane biomimetic nanocarrier, loaded with L-arginine and γ-Fe2O3 nanoparticles (PAMNs), has been developed for delineating injury acute Due loading of nanoparticles, multi-parameter MRI including T2*-weighted (T2* WI) diffusion-weighted (DWI) have used localize stroke lesion evaluate severity vasuclar network, respectively. Results demonstrated that PAMNs can specifically target different types blood vasculature. Based accumulation lesion, T2* delineated espcially penumbra. Furthermore, release DWI was applied pre-protection effect. This showed great potential accurate positioning real-time monitoring lesions. Therefore, PAMNs-based technique feasible obstruction/thrombus location, assessment, development lesions early stage